Multiple Ascending Doses of AMG 139 in Healthy and Crohn's Disease Subjects

Inclusion Criteria

• Part A – Healthy Subjects:
• - Healthy male or female of non-reproductive potential subjects between 18 to 45 years-of-age
• - Body mass index (BMI) between 18 and 32 kg/m2
• - Normal or clinically acceptable physical examination, clinical laboratory values, and ECG
• - Additional inclusion criteria apply
• Part B – Crohn’s Subjects:
• - Male or female subjects with CD between 18 to 55 years-of-age
• - Body mass index (BMI) between 18 and 32 kg/m2
• - Normal or clinically acceptable physical examination (PE), clinical laboratory values, and ECG; clinically acceptable PE includes evidence of mild to severe CD
• - Diagnosis of ileal or ileo-colonic CD for a minimum of 6 months
• - Mild to severe CD defined by a Crohn’s Disease Activity Index (CDAI) score equal to or greater than 180 and equal to or less than 450
• - Elevated fecal calprotectin and CRP
• - Additional inclusion criteria apply