Prospective Tissue Collection Research Protocol

Exclusion Criteria

• -Clinical status precludes surgical removal of, or collection of multiple biopsies from, accessible tumour tissue.
• -Inadequate peripheral venous access precluding collection of blood.
• -Pregnant or breastfeeding women.
• -Known/laboratory confirmed diagnosis of an active infectious disease to include Hepatitis B and C, human immunodeficiency virus infection (HIV1/2), Human t-lymphotropic virus (HTLV I/II) and syphilis.
• -Patients who are currently participating in a clinical trial involving an unlicensed medical product.
• -Patients who have received any cytotoxic therapy (including investigational products) within three weeks prior to tissue procurement.
• -Patients receiving immunosuppressive treatments or who require regular treatment with steroids at a dose higher than prednisolone 10 mg/day (or equivalent).
• -Any medical reason why, in the opinion of the investigator, the patient should not participate in this study.
• -For selected solid tumours and leukapheresis procedure additional exclusion criteria apply.