A study to screen for lung cancer in high-risk individuals who have never smoked using low-dose computed tomography (LDCT). - NEMO

Inclusion Criteria

• Inclusion Criteria:
• - - Sign and date the informed consent form before any study-specific procedure.
• - - Be a never-smoker, defined as an individual who has smoked fewer than 100 cigarettes in their lifetime and who has no history of regular use of cigars, pipes, straw cigarettes, or hookahs.
• - - Men aged 50 to 74 or women aged 40 to 74 at the time of enrollment.
• - - Meet at least one of the following high-risk criteria: A first-degree relative or two second-degree relatives diagnosed with lung cancer; Current or previous occupational exposure to asbestos, nickel, arsenic, beryllium, silica, or chromium for at least 1 year; Exposure for more than five years to household smoke from coal or firewood, foundry smoke, or comparable industrial smoke; Known germline mutation in genes associated with an increased risk of lung cancer, including TP53, BRCA1, BRCA2, or ATM.
• - - Be physically and medically capable of undergoing a chest CT scan in the supine position.
• - - Be available for follow-up according to the study schedule.
• Exclusion Criteria:
• - - Previous diagnosis of invasive cancer, except for in situ neoplasms or treated non-melanoma skin tumors, when deemed clinically irrelevant by the investigator.
• - - History of using cigars, pipes, straw cigarettes, or hookahs on more than 100 occasions throughout their lifetime, or regular use (≥ 1 time per week for ≥ 6 consecutive months).
• - - Physical inability to remain in the supine position during a chest CT scan.
• - - Inability to understand, sign, or maintain informed consent.
• - - A clinical condition that, in the investigator's judgment, precludes the safe performance of study procedures or the planned follow-up.