AZD2423 Safety and Tolerability Study in patients with moderate and severe Chronic Obstructive Pulmonary Disease(COPD)

Exclusion Criteria

• - Any clinically significant disease or disorder (including history of abnormal immune function) which, in the opinion of the Investigator, may either put the subject at risk or influence the way the drug works
• - Any lung disease other than COPD, recent respiratory infections which have not resolved fully, active tuberculosis or at risk of reactivation of tuberculosis.
• - Any abnormal findings in physical examination, blood or urine test results, vital signs or ECG at Visit 1 that may put the subject at risk during the study, affect their ability to take part or influence the results of the study
• - Immunisation with a live vaccine within 3 months or other vaccination within 30 days before planned start of treatment
• - Worsening of COPD symptoms within 4 weeks prior to start of study needing hospitalisation, oral steroids or antibiotics.