Study to see if platelet transfusion stop or lessen the effect of the drug on platelets

Exclusion Criteria

• - ADP induced platelet aggregation <60% prior to platelet apheresis
• - History of peptic ulcer disease Healthy volunteers with a propensity to bleed (eg, due to recent trauma, recent surgery, active or recent gastrointestinal bleeding or moderate hepatic impairment)
• - Any clinically significant illness, medical/surgical procedure or trauma within 4 weeks of the first administration of the investigational product
• - Current smokers, those who have smoked or used nicotine products within the previous 3 months and those who tested positive for cotinine at screening or at admission to the study center