[SOCRATES –Acute Stroke Or Transient IsChaemic Attack TReated with Aspirin or Ticagrelor and Patient OutcomES] - SOCRATES

Exclusion Criteria

• Inclusion Criteria:
• - Men or women equal or elder 40 years of age
• - Either acute ischaemic stroke or high-risk TIA as defined here and randomisation occurring within
• 24 hours after onset of symptoms
• - Planned use of antithrombotic therapy in addition to study medication including
• antiplatelets (eg, open label ASA, GPIIb/IIIa inhibitors, clopidogrel, ticlopidine,
• prasugrel, dipyridamole, ozagrel, cilostazol) and anticoagulants (eg, warfarin, oral
• thrombin and factor Xa inhibitors, bivalirudin, hirudin, argatroban, unfractionated
• and low molecular weight heparins). - Any history of atrial fibrillation, ventricular aneurysm or suspicion of cardioembolic pathology for TIA or stroke. - Planned carotid, cerebrovascular, or coronary revascularisation that requires halting study medication within 7 days of randomisation. - Receipt of any intravenous or intra-arterial thrombolysis or mechanical thrombectomy within 24 hours prior to randomisation - History of previous symptomatic non-traumatic intracerebral bleed at any time (asymptomatic microbleeds do not qualify), gastrointestinal (GI) bleed within the past 6 months, or major surgery within 30 days.