A study to evaluate the Efficacy, Safety, and Pharmacokinetics of AZD0780 in Participants with Dyslipidaemia

Study identifier:D7960C00008

ClinicalTrials.gov identifier:NCT06834932

EudraCT identifier:N/A

CTIS identifier:N/A

Recruiting

Official Title

A Randomised, Double-blind, Placebo-controlled, Multi-centre, Sequential Phase II, and Phase III Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of AZD0780 Administered for up to 52 Weeks in Participants with Dyslipidaemia (AZURE-CHINA)

Medical condition

dyslipidaemia

Phase

Phase 2/3

Healthy volunteers

Study drug

Placebo, Rosuvastatin Dose 1, Rosuvastatin dose 2, AZD0780

Sex

All

Estimated Enrollment

300

Study type

Interventional

Age

18 Years - n/a

Date

Study Start Date: 06 Dec 2024

Estimated Primary Completion Date: 18 Jun 2027

Estimated Study Completion Date: 18 Jun 2027

Study design

Allocation: Randomized
Endpoint Classification: -
Intervention Model: Parallel Assignment
Masking: -
Primary Purpose: Treatment

Verification:

Verified 01 Aug 2025 by AstraZeneca

Collaborators

Inclusion and exclusion criteria

Inclusion Criteria

PART A
1. Males, and females of non-childbearing potential, 18 to 55 years of age, at the time of signing the informed consent.
2. Diagnosis of dyslipidaemia: and with fasting LDL-C ≥ 100 mg/dL (2.6 mmol/L) and < 190 mg/dL (4.9 mmol/L) at screening (Visit 1).
3. Fasting triglycerides < 400 mg/dL (< 4.52 mmol/L) at screening (Visit 1).
4. Not on any LLTs for ≥ 8 weeks prior to screening (Visit 1), except for a heart-healthy lifestyle.
5. No planned LLTs using during study participation.
6. Body mass index ≥ 18 and ≤35 kg/m^2 , weigh ≥50 kg and ≤120 kg.
PART B
1. Males, and females, ≥ 18 years of age, at the time of signing the informed consent.
2. Meets one of the ASCVD status/risk categories and has a corresponding fasted LDL-C value at screening (Visit 1) .
(1) Participants with clinical ASCVD, LDL-C ≥ 55 mg/dl (ultra-high risk) and ≥ 70 mg/dl (very high risk).
(2) Participants without clinical ASCVD, at moderate to high risk for ASCVD at 10 years, LDL-C ≥ 100 mg/dl. ASCVD risk equivalents [diabetes mellitus,LDL-C ≥ 4.9 mmol/L or TC ≥ 7.2 mmol/L, HeFH, CKD (stage 3-5)] are also eligible.
3. Fasting triglycerides < 400 mg/dL (< 4.52 mmol/L).
4. Background LLTs:
For Cohort 1: on a stable dose of LLTs including medications and supplements ≥ 28 days before screening (Visit 1). , that typically include moderate to high-intensity statins for ≥ 28 days before screening (LLTs include medications [eg, statins, ezetimibe, niacin] and supplements [eg, omega-3 fatty acids] that can affect cholesterol levels).
(1) Participants intolerant to moderate or high intensity statins per the 2023 Chinese Guideline may be included if treated with a low intensity statin.
(2) Participants not on statins must have documented intolerance to at least two statins (including one at the lowest standard dose) or be on chronic medication contraindicating statin use.
For Cohort 2: Meet one of the following before screening (Visit 1):
(1) On a stable dose of LLTs including moderate statins .
(2) On a stable dose of LLTs without any statins.
(3) Not received treatment with any LLTs.

Exclusion Criteria

PART A
1. Malignancy (except non-melanoma skin cancers, cervical in-situ carcinoma, breast ductal carcinoma in-situ, or Stage 1 prostate carcinoma) within the last 10 years.
2. Recipient of any major organ transplant, eg, lung, liver, heart, bone marrow, renal.
3. Homozygous familial hypercholesterolaemia, Know diagnosis of HeFH, LDL apheresis or plasma apheresis within 12 months prior to screening (Visit 1).
4. QTcF > 450 ms; high degree atrioventricular-block grade II-III and sinus node dysfunction with significant sinus pause untreated with pacemaker; and cardiac tachyarrhythmias.
5. A LDL-C reduction that is < 30% post rosuvastatin run-in period (Day -8).
PART B
1. Acute ischaemic ASCVD event within 7 days prior to screening (Visit 1).
2. Any uncontrolled or serious disease.
3. eGFR < 15 mL/min/1.73m2 using the CKD-EPI 2021 (age, sex) equation at screening (Visit 1).
4. Uncontrolled type 2 diabetes mellitus, defined as HbA1c ≥ 9.5% at screening (Visit 1).
5. Heart failure with New York Heart Association Class IV.
6. Malignancy (except non-melanoma skin cancers, cervical in-situ carcinoma) within 5 years prior to screening (Visit 1).
7. Severe concomitant non-CVD with risk of life expectancy < 2 years.
8. Recipient of any major organ transplant, eg, lung, liver, heart, bone marrow, renal.
9. Homozygous familial hypercholesterolaemia, LDL apheresis, or plasma apheresis within 12 months prior to screening or any other underlying known disease or condition that may interfere with interpretation of the clinical study results as judged by the Investigator.
10. Uncontrolled hypertension defined as average sitting SBP > 160 mmHg or DBP > 110 mmHg at screening (Visit 1) or randomization despite antihypertensive therapy (based on the mean of the 3 consecutive readings).
11. Any laboratory values with the following deviations at screening (Visit 1)
(a) Any positive result on screening for hepatitis B or hepatitis C.
(b) ALT > 3 × ULN.
(c) AST > 3 × ULN.
(d) TBL > 2 × ULN (except for participants with Gilberts syndrome, where TBL 3 × ULN is acceptable provided direct bilirubin < 1.5 × ULN)
(e) Creatine kinase > 5 × ULN
(f)Urine albumin-to-creatinine ratio ≥ 500 mg/g
12. QTcF > 470 ms; high degree atrioventricular-block grade II-III and sinus node dysfunction with significant sinus pause untreated with pacemaker; and cardiac tachyarrhythmias.
13. Current administration of PCSK9 inhibitor, siRNA or mAb (approved or investigational) at screening.
14. Mipomersen or microsomal triglyceride transfer protein inhibitor (eg, lomitapide) use within 12 months prior to screening or planned ues during the study.
15. Use of PCSK-9 inhibitors: evolocumab/alirocumab within 12 weeks, inclisiran within 18 months, tafolecimab, ebronucimab, ongericimab, and recaticimab within 3 to 6 months before screening or planned use during the study; or any other PCSK-9 inhibitor within 5 half-lives before screening or planned use during the study.
16. Use of any lipid-lowing traditional Chinese medicine (expect Xuezhikang) within 8 weeks before screening.
17. Use of gemfibrozil within one week before screening or planned use during the study.
18. Receiving, or has received within 14 days of screening, medication with a black box warning for significant QT prolongation.

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Arms	Assigned Interventions
Experimental: AZD0780 +Rosuvastatin Dose 1 (Part A) • Participants will receive Rosuvastatin Dose 1 QD for minimum 21 days (up to 28 days) • Then receive AZD0780 QD as add on for next 28 days (Part A)	Drug: Rosuvastatin Dose 1 Administered orally as tablets Drug: AZD0780 Administered orally as tablets
Placebo Comparator: Placebo +Rosuvastatin Dose 1 (Part A) • Participants will receive Rosuvastatin Dose 1 QD for minimum 21 days (up to 28 days) • Then receive Placebo QD as add on for next 28 days (Part A)	Drug: Placebo Administered orally as tablets Drug: Rosuvastatin Dose 1 Administered orally as tablets
Experimental: AZD0780 +Rosuvastatin Dose 2 (Part A) • Participants will receive Rosuvastatin Dose 2 QD for minimum 21 days (up to 28 days) • Then receive AZD0780 QD as add on for next for 28 days (Part A)	Drug: Rosuvastatin dose 2 Administered orally as tablets Drug: AZD0780 Administered orally as tablets
Placebo Comparator: Placebo + Rosuvastatin Dose 2 (Part A) • Participants will receive Rosuvastatin Dose 2 QD for minimum 21 days (up to 28 days) • Then receive Placebo QD as add on for 28 days (Part A)	Drug: Placebo Administered orally as tablets Drug: Rosuvastatin dose 2 Administered orally as tablets
Experimental: AZD0780 (Part B Cohort 1) • Participate will receive AZD0780 QD for 52 weeks (Part B Cohort 1)	Drug: AZD0780 Administered orally as tablets
Placebo Comparator: Placebo (Part B Cohort 1) • Participate will receive Placebo QD for 52 weeks (Part B Cohort 1)	Drug: Placebo Administered orally as tablets
Experimental: AZD0780+Rosuvastatin Dose 1 (Part B Cohort 2) • Participate receive Rosuvastatin Dose 1 for 28 days. • Then receive AZD0780 QD as add on for 12 weeks (Part B Cohort 2)	Drug: Rosuvastatin Dose 1 Administered orally as tablets Drug: AZD0780 Administered orally as tablets
Placebo Comparator: Placebo+Rosuvastation Dose 1 (Part B Cohort 2) • Participate receive Rosuvastatin Dose 1 for 28 days. • Then receive Placebo QD as add on for 12 weeks (Part B Cohort 2)	Drug: Placebo Administered orally as tablets Drug: Rosuvastatin Dose 1 Administered orally as tablets

Documents available

Trial Results Summaries
Available here

Contacts

Contact

AstraZeneca Clinical Study Information Center

1-877-240-9479

[email protected]