A Study of Novel Study Interventions and Combinations in Participants with Colorectal Cancer - CANTOR

Exclusion Criteria

• • Central nervous system metastases or spinal cord compression
• • Known history of severe allergy to any monoclonal antibody or study intervention.
• • Any unresolved toxicity CTCAE Grade ≥ 2 from a previous anticancer therapy.
• • History of another primary malignancy.
• Substudy Exclusion Criteria:
• • Potentially resectable disease with multidisciplinary plan for radical surgery.
• • Active or prior documented autoimmune or inflammatory disorders or cardiac conditions.
• • Participants with a prior history of hypertensive crisis or hypertensive encephalopathy or bleeding risks.
• • Deep venous thrombosis, pulmonary embolism, arterial thrombosis, transient ischemic attack or cerebrovascular accident.
• • History of abdominal or tracheoesophageal fistula, GI perforation and/or fistulae, or intraabdominal abscess within 6 months prior to randomization.
• • Prior exposure to immune mediated therapy.