Pharmacokinetics and Safety Study of PT010 and PT003 in Healthy Chinese Adult Subjects

Exclusion Criteria

• -Pregnant or nursing female subjects or subjects who are trying to conceive
• -Subjects with clinically significant neurologic, cardiovascular, hepatic, renal, endocrinologic, pulmonary, hematological, psychiatric, or other medical illness that would interfere with participation in this study
• -Subjects with a history of ECG abnormalities
• -Subjects who have cancer that has not been in complete remission for at least 5 years
• -Male subjects with symptomatic prostatic hypertrophy that is clinically significant in the opinion of the Investigator
• -Male subjects with a trans-urethral resection of the prostate or full resection of the prostate within 6 months prior to Screening
• -Males with bladder neck obstruction or urinary retention that is clinically significant in the opinion of the Investigator
• -Subjects with a diagnosis of glaucoma that in the opinion of the Investigator has not been adequately treated
• -History of substance-related disorders within 1 year of Screening
• -History of smoking or the use of nicotine containing products or electronic cigarettes within 3 months of Screening by self-reporting
• -A positive alcohol breathalyzer or urine drug screen for drugs of abuse at the Screening Visit or at the beginning of each inpatient period
• -Treatment with any prescription or non-prescription drugs (including vitamins, herbal, and dietary supplements) within 30 days
• -Positivity for human immunodeficiency virus (HIV) or Hepatitis B surface antigen (HbsAg) or positive hepatitis C antibody at Screening
• -Positive for Syphilis Antibody
• -Subjects with any flu-like syndrome or other respiratory infections
• -Recently vaccinated with an attenuated live virus